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Autonomic Nervous System Pharmacology MCQs
Notes · Pharm-D / Pharmacy · 24 practice questions
- Adrenergic Receptor Subtypes
- Cholinergic Receptor Pharmacology
- Pheochromocytoma Management
- Dobutamine vs dopamine pharmacology
- Pheochromocytoma perioperative management
- Atropine Pharmacology
- Adrenergic receptor pharmacology - alpha receptors
- Neostigmine and Neuromuscular Reversal
1. A patient who received a non-depolarizing neuromuscular blocker during surgery is given neostigmine postoperatively to reverse the block. Glycopyrrolate is co-administered. What is the primary rationale for adding glycopyrrolate?
- ATo reverse residual nicotinic blockade at the neuromuscular junction
- BTo prevent neostigmine-induced hypertension via alpha-1 stimulation
- CTo enhance neostigmine's penetration into the CNS
- DTo blunt muscarinic effects such as bradycardia and bronchorrhea caused by neostigmine
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D. To blunt muscarinic effects such as bradycardia and bronchorrhea caused by neostigmine Neostigmine is invariably co-administered with glycopyrrolate or atropine to blunt concurrent muscarinic effects such as bradycardia and bronchorrhea.
2. A 68-year-old man with COPD is prescribed a muscarinic antagonist to reduce bronchoconstriction. Which second-messenger pathway is most directly responsible for the bronchoconstriction that this drug is intended to block?
- ADirect ligand-gated cation influx
- BIncreased cAMP via Gs
- CIncreased phospholipase C activity and intracellular calcium via Gq
- DDecreased cAMP via Gi
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C. Increased phospholipase C activity and intracellular calcium via Gq M3 receptors in bronchial smooth muscle are Gq-coupled and increase phospholipase C activity and intracellular calcium, mediating bronchoconstriction.
3. A patient with hypertension is started on clonidine. Which receptor and signaling mechanism most directly explains its centrally-acting antihypertensive effect?
- ABeta-2 receptors, Gs, causing vasodilation
- BBeta-1 receptors, Gs, increasing cAMP
- CAlpha-2 receptors, Gi, decreasing norepinephrine release
- DAlpha-1 receptors, Gq, increasing intracellular calcium
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C. Alpha-2 receptors, Gi, decreasing norepinephrine release Alpha-2 receptors are Gi-coupled, provide presynaptic negative feedback inhibition of norepinephrine release, and mediate the centrally-acting antihypertensive effect of clonidine.
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