Practice questions › Davidson's Principles of Medicine › Davidson's Medicine - Part 3: Clinical Medicine
13 Infectious disease MCQs
Davidson's Medicine - Part 3: Clinical Medicine · Davidson's Principles of Medicine · 10 practice questions
- Herpesviruses
- Exposure and infection
- Filariasis
- Protozoal infections
- Viral and bacterial infections
- Filariasis and fungi
- Malaria
- Diphtheria
1. A patient with localised herpes labialis presents on day 5 and a patient with AIDS has Kaposi's sarcoma. Which statements are correct?
- ATherapy works at any time; Kaposi's sarcoma is caused by EBV
- BLocalised disease therapy should start within 48 hours whereas severe disease is always treated; Kaposi's sarcoma is caused by HHV-8
- COnly IV therapy works; Kaposi's sarcoma is caused by HPV
- DTherapy is never needed; Kaposi's sarcoma is caused by CMV
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B. Localised disease therapy should start within 48 hours whereas severe disease is always treated; Kaposi's sarcoma is caused by HHV-8 Localised disease therapy is unlikely to influence outcome after 48 hours; HHV-8 causes Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease.
2. A 32-year-old injection drug user has fever, a new murmur and cough. Which empirical therapy and duration for uncomplicated right-sided MSSA endocarditis does the text describe?
- AGentamicin alone for 1 week
- BAn antistaphylococcal penicillin such as flucloxacillin, or vancomycin or daptomycin if MRSA prevalent; MSSA treated with high-dose IV flucloxacillin for 2 weeks
- CCeftriaxone for 6 weeks
- DPenicillin for 4 days
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B. An antistaphylococcal penicillin such as flucloxacillin, or vancomycin or daptomycin if MRSA prevalent; MSSA treated with high-dose IV flucloxacillin for 2 weeks Empirical therapy is an antistaphylococcal penicillin or a glycopeptide/lipopeptide where MRSA is prevalent; 2 weeks for uncomplicated right-sided MSSA endocarditis and 4 weeks vancomycin for MRSA.
3. A patient with shingles presents within 48 hours aged 75. Another has HSV encephalitis with haemorrhagic temporal lobe changes. Which statements are correct?
- AEarly aciclovir reduces early and late pain but steroids do not reduce postherpetic neuralgia; HSV encephalitis is diagnosed by positive CSF PCR with untreated mortality of 80%
- BAntibiotics help shingles; encephalitis is diagnosed by culture with mortality 50%
- CAnalgesia only for shingles; encephalitis mortality 20%
- DSteroids prevent postherpetic neuralgia; HSV encephalitis is diagnosed by serology with mortality 5%
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A. Early aciclovir reduces early and late pain but steroids do not reduce postherpetic neuralgia; HSV encephalitis is diagnosed by positive CSF PCR with untreated mortality of 80% Early antiviral therapy reduces pain especially over 65; glucocorticoids have not been shown to reduce postherpetic neuralgia; HSV encephalitis needs immediate antiviral therapy.
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